Wiedenheft LabMicrobiology & Cell Biology

Structures

30 structures, 2004–2026

Every structure the lab has deposited in the Protein Data Bank, drawn here from the deposited coordinates. The record runs from early X-ray crystal structures of proteins from viruses that infect archaea (Sulfolobus spindle-shaped virus, 2004) to 17 cryo-EM structures of immune complexes. Select any structure to turn it around in 3D.

3D model of PDB 9NLV: SenDRT9 RT–ncRNA hexamer

Now showing

SenDRT9 RT–ncRNA hexamer

PDB
9NLV
Method
Cryo-EM
Resolution
2.6 Å
Released
2025-05-14

Protein-primed homopolymer synthesis by an antiviral reverse transcriptase. Nature 2025

Open in RCSB PDB

Resolution of each structure, by release dateLower is sharper. Select a dot to load that structure in the viewer. X-ray crystallographyCryo-EM
2 Å3 Å4 Å20052010201520202025First cryo-EM structure from the lab, 2017

All entries

The full list

Newest first. Thumbnails show the backbone of each deposited model: identical subunits share a colour, and DNA and RNA are gold.

  • 9Z7XCryo-EM · 2.9 Å

    Type III-Bv CRISPR complex

    Structure 2026 · released 2026

    RCSB PDB Paper

  • 9Z7VCryo-EM · 3.0 Å

    Type III-Bv CRISPR complex

    Structure 2026 · released 2026

    RCSB PDB Paper

  • 9Z7QCryo-EM · 3.0 Å

    Type III-Bv CRISPR complex

    Structure 2026 · released 2026

    RCSB PDB Paper

  • 9P1DCryo-EM · 3.3 Å

    Cas1–Cas2/3 integrase with foreign DNA

    Structure 2025 · released 2025

    RCSB PDB Paper

  • 9P11Cryo-EM · 3.5 Å

    Cas1–Cas2/3 integrase, heterohexamer

    Structure 2025 · released 2025

    RCSB PDB Paper

  • 9ARWCryo-EM · 3.8 Å

    Guideless DtCmr type III complex

    Unpublished · released 2025

    RCSB PDB

  • 9NLXCryo-EM · 3.2 Å

    SenDRT9 RT–ncRNA trimer

    Nature 2025 · released 2025

    RCSB PDB Paper

  • 9NLVCryo-EM · 2.6 Å

    SenDRT9 RT–ncRNA hexamer

    Nature 2025 · released 2025

    RCSB PDB Paper

  • 9N6CCryo-EM · 3.0 Å

    Retron I-A complex without the HNH nuclease

    Nature Communications 2025 · released 2025

    RCSB PDB Paper

  • 9N6BCryo-EM · 3.1 Å

    Retron I-A complex, HNH nuclease “up”

    Nature Communications 2025 · released 2025

    RCSB PDB Paper

  • 9N69Cryo-EM · 3.1 Å

    Retron I-A complex, HNH nuclease “down”

    Nature Communications 2025 · released 2025

    RCSB PDB Paper

  • 8UX9Cryo-EM · 3.2 Å

    PARIS immune complex (AriA6–AriB3)

    Nature 2024 · released 2024

    RCSB PDB Paper

  • 8FLJCryo-EM · 3.5 Å

    Cas1–Cas2/3 integrase with IHF and CRISPR leader DNA

    Nature Structural & Molecular Biology 2023 · released 2023

    RCSB PDB Paper

  • 6WHICryo-EM · 4.2 Å

    Type I-F Csy surveillance complex

    Nature Communications 2020 · released 2020

    RCSB PDB Paper

  • 6W1XCryo-EM · 3.9 Å

    Anti-CRISPR AcrIF9 bound to the Csy complex

    Nature Communications 2020 · released 2020

    RCSB PDB Paper

  • 6NE0Cryo-EM · 3.4 Å

    Csy complex engaged with target DNA

    Molecular Cell 2019 · released 2018

    RCSB PDB Paper

  • 5UZ9Cryo-EM · 3.4 Å

    Anti-CRISPRs AcrF1 and AcrF2 bound to Csy

    Cell 2017 · released 2017

    RCSB PDB Paper

  • 5H9FX-ray · 2.5 Å

    Cascade bound to PAM-containing DNA

    Nature 2016 · released 2016

    RCSB PDB Paper

  • 5H9EX-ray · 3.2 Å

    Cascade bound to PAM-containing DNA

    Nature 2016 · released 2016

    RCSB PDB Paper

  • 5CD4X-ray · 3.2 Å

    E. coli type I-E Cascade complex

    Nucleic Acids Research 2015 · released 2015

    RCSB PDB Paper

  • 4TVXX-ray · 3.2 Å

    E. coli Cascade surveillance complex

    Science 2014 · released 2014

    RCSB PDB Paper

  • 4AN8X-ray · 2.3 Å

    Thermus thermophilus CasA (Cse1)

    Molecular Cell 2012 · released 2012

    RCSB PDB Paper

  • 2XLKX-ray · 1.8 Å

    Csy4 bound to crRNA

    Science 2010 · released 2010

    RCSB PDB Paper

  • 2XLJX-ray · 2.6 Å

    Csy4 bound to crRNA

    Science 2010 · released 2010

    RCSB PDB Paper

  • 2XLIX-ray · 2.3 Å

    Csy4 bound to crRNA

    Science 2010 · released 2010

    RCSB PDB Paper

  • 3GODX-ray · 2.2 Å

    Cas1, a CRISPR-associated DNase

    Structure 2009 · released 2009

    RCSB PDB Paper

  • 2VQCX-ray · 2.3 Å

    SSV F-112 winged-helix DNA-binding protein

    Virology 2008 · released 2008

    RCSB PDB Paper

  • 2CLBX-ray · 2.4 Å

    Dps-like protein from Sulfolobus solfataricus

    Biochemistry 2006 · released 2006

    RCSB PDB Paper

  • 1TBXX-ray · 2.7 Å

    SSV1 F-93 protein

    Journal of Virology 2004 · released 2004

    RCSB PDB Paper

  • 1SKVX-ray · 2.6 Å

    SSV1 D-63 protein

    Journal of Virology 2004 · released 2004

    RCSB PDB Paper